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The average fatal dose of hydrogen cyanide is


A) 5 to 10 mg.
B) 50 mg.
C) 5 to 20 g.
D) 200 to 300 g.

E) A) and B)
F) A) and C)

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Actylcholinesterase acts to change acetylcholine to


A) acetic acid, water and choline.
B) water and choline.
C) water and acetic acid.
D) acetic acid and choline.

E) A) and C)
F) C) and D)

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Which of the following is NOT used to gather evidence about whether a compound causes cancer in humans?


A) bacterial screening for mutagenesis (the Ames test)
B) animal tests
C) measurement of birth defects
D) epidemiological studies

E) All of the above
F) A) and B)

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The Ames test is used to screen for


A) all potential poisons.
B) heavy metal poisons.
C) mutagens.
D) carcinogens.

E) B) and D)
F) C) and D)

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Which of the following statements best describes the circumstances that lead to chemical tragedies?


A) Hazardous and poisonous chemicals should be banned or destroyed so that accidents do not occur.
B) Most tragedies occur because of misuse of hazardous or poisonous chemicals.
C) Hazardous and poisonous chemicals cannot be made safe.
D) The risks of using hazardous chemicals always outweigh the benefits.

E) A) and B)
F) All of the above

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Which of the following amino acids undergoes oxidation in the presence of photochemical smog?


A) tryptophan
B) glycine
C) leucine
D) threonine

E) A) and B)
F) A) and C)

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Which of the following will make the most effective poison for rats and mice?


A) ethyl alcohol, LD50 = 2.08 g/kg
B) acetaminophen, LD50 = 0.340 g/kg
C) ethylene glycol, LD50 = 0.00686 g/kg
D) ricin, LD50 = 0.000005 mg/kg

E) All of the above
F) A) and C)

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Which of the following will have anticarcinogenic activity?


A) aromatic amines, such as β-naphthylamine
B) oncogenes
C) vitamin C, vitamin E, and β-carotene
D) polycyclic aromatic hydrocarbons, such as 3,4-benzopyrene

E) All of the above
F) C) and D)

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What type of damage do all corrosive poisons cause to living tissue?

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Corrosives cause the...

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The LD50 value for a given compound and species is the same no matter how the substance is administered.

A) True
B) False

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Cyanide acts by blocking the oxidation of glucose in the cell.

A) True
B) False

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A teratogen is a cancer-causing substance.

A) True
B) False

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The best way to handle hazardous wastes is


A) to bury them.
B) to incinerate them.
C) to chemically modify them.
D) to avoid producing them.

E) A) and B)
F) A) and C)

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The antidote for mercury poisoning is


A) atropine.
B) nicotine.
C) BAL.
D) coniine.

E) B) and C)
F) C) and D)

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If a compound is a carcinogen in rats, it will also be a carcinogen for mice.

A) True
B) False

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Which of the following statements about the role of liver enzymes is most correct?


A) Liver enzymes always change potential toxins to substances that can be easily excreted from the body.
B) Liver enzymes may change an inert compound to a more reactive and harmful molecule.
C) Liver enzymes can help the body to bring the four humors (blood, phlegm, black bile and yellow bile) back into a healthy balance.
D) Liver enzymes always convert potential toxins to substances that contain free radicals.

E) A) and B)
F) A) and C)

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Cyanides increase the ability of hemoglobin to carry oxygen.

A) True
B) False

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The study of the effects of poisons, their detection and identification and their antidotes is known as


A) alkaloidism.
B) carcinogenic testing.
C) berylliosis.
D) toxicology.

E) A) and B)
F) B) and C)

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In the body, ethanol goes through the following steps.


A) ethanol \rightarrow acetic acid \rightarrow acetaldehyde \rightarrow carbon dioxide and water
B) ethanol \rightarrow carbon dioxide and water \rightarrow acetaldehyde \rightarrow acetic acid
C) ethanol \rightarrow acetic acid \rightarrow carbon dioxide and water \rightarrow acetaldehyde
D) ethanol \rightarrow acetaldehyde \rightarrow acetic acid \rightarrow carbon dioxide and water

E) A) and B)
F) C) and D)

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An example of an alkaloid is


A) estradiol.
B) acetic acid.
C) methionine.
D) caffeine.

E) C) and D)
F) A) and B)

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